Novel Approach for Synthesis of (+/-)-Calanolide A and Its Anti-HIV Activity

DOI: 10.1016/00404-0399(50)1059Q-

Source and publish data:

Tetrahedron Letters p. 5475 - 5478 (1995)

Update date:2022-08-16

Topics:

Authors:

Kucherenko, Alla

Flavin, Michael T.

Boulanger, William A.

Khilevich, Albert

Shone, Robert L.

et al. et al.

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Article abstract of DOI:10.1016/00404-0399(50)1059Q-

Anti-HIV agent (+/-)-calanolide A (1) has been synthesized.The key intermediate, chromone 5, was synthesized by the sequence of Pechmann reaction, acylation and chromenylation by 4,4-dimethoxy-2-methylbutan-2-ol.The anti-HIV activity for synthetic (+/-)-1 has been determined and compared with the natural product.

Full text of DOI:10.1016/00404-0399(50)1059Q-

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