Journal of Fluorine Chemistry p. 129 - 132 (1994)
Update date:2022-08-28
Topics:
Murata, Kouichi
Kitazume, Tomoya
Fluorination of β-thujaplicin with diethylaminosulfur trifluoride (DAST) gave 2-fluoro-4-isopropyltropone and 2-fluoro-6-isopropyltropone (1:1 mixture; 60percent).The relationships between the antibacterial activities and conformations of β-thujaplicin and its fluorinated analogs are discussed. - Keywords: Conformational effects; Biological activity; β-Thujaplicin; Fluorination; NMR spectroscopy; Semi-empirical MO calculations
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