Synthesis of new α-amino- acids containing the isoxazole moiety

Article abstract of DOI:10.1016/S0040-4039(98)02010-3

Methodology for preparing a series of novel α-amino-acids and their derivatives containing an isoxazole ring as a substituent is presented. The synthesis starts from a readily available L-serine derivative from which, depending on the synthetic strategy, it is possible to obtain isoxazol-3-yl or isoxazol-5-yl amino-acid precursors.