Synthesis of nucleotide lipophilic prodrugs containing two inhibitors targeted against different phases of the HIV replication cycle

Article abstract of DOI:10.1080/15257779508012471

We describe the preparation of nucleoside acyl 5'-di or 5'-triphosphates, containing a nucleoside analog moiety and 13-oxa-myristic acid as lipophilic chain. At physiological pH these products liberated exclusively the corresponding nucleotides.

Full text of DOI:10.1080/15257779508012471

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Nucleosides and Nucleotides
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Synthesis of Nucleotide Lipophilic
Prodrugs Containing Two Inhibitors
Targeted Against Different Phases of the
HIV Replication Cycle
D. Bonnaffé a b , B. Dupraz a , J. Ughetto-Monfrin a , A. Namane a &
T. Huynh Dinh a
a Unité de Chimie Organique, URA CNRS 487 , Institut Pasteur 28 rue
du Docteur Roux , 75724, Paris Cedex, 15, France
b Laboratoire de Chimie Organique Multifonctionnelle , URA CNRS
462, Bat 420 Université , Paris Sud, 91405, Orsay Cedex
Published online: 16 Feb 2007.
To cite this article: D. Bonnaffé , B. Dupraz , J. Ughetto-Monfrin , A. Namane & T. Huynh Dinh (1995)
Synthesis of Nucleotide Lipophilic Prodrugs Containing Two Inhibitors Targeted Against Different
Phases of the HIV Replication Cycle, Nucleosides and Nucleotides, 14:3-5, 783-787
To link to this article: http://dx.doi.org/10.1080/15257779508012471
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