Total Synthesis of 11-R,12-R-Dihydroxyeicosatrienoic Acid, A Metabolite of the Cytochrome P-450 Epoxygenase Pathway

Article abstract of DOI:10.1016/S0040-4039(00)73401-0

The first total and enantioselective synthesis of 11-R,12-R-dihydroxy-5,8,14-eicosatrienoic acid 7 is reported.We have used the carbohydrate 2-deoxy-D-glucose as a masked 1,6-dialdehyde precursor 20 to perform the synthesis.The availability of this material will allow, among other things, the testing of the hypothesis that it can be a biochemical precursor to 12-R-HETE in vivo.