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ABBREVIATIONS
Journal of Medicinal Chemistry
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ALK, anaplastic lymphoma kinase; ALKi, anaplastic lymphoma kinase inhibitor; NPM, nucleoplasmin; EML4, echinoderm micro-
tubule-associated protein-like 4; ALCL, anaplastic large cell lymphoma; NSCLC, non-small-cell lung cancer; DLBCL, diffuse large
b-cell lymphoma; IMT, microfibroblastic tumor.
REFERENCES
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1.
Morris, S. W.; Naeve, C.; Mathew, P.; James, P. L.; Kirstein, M. N.; Cui, X. L.; Witte, D. P., ALK, the chromosome 2 gene locus
altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte
tyrosine kinase (LTK). Oncogene 1997, 14 (18), 2175-2188.
2.
Bilsland, J. G.; Wheeldon, A.; Mead, A.; Znamenskiy, P.; Almond, S.; Waters, K. A.; Thakur, M.; Beaumont, V.; Bonnert, T. P.;
Heavens, R.; Whiting, P.; McAllister, G.; Munoz-Sanjuan, I., Behavioral and neurochemical alterations in mice deficient in anaplastic
lymphoma kinase suggest therapeutic potential for psychiatric indications. Neuropsychopharmacology 2008, 33 (3), 685-700.
3.
Kwak, E. L.; Bang, Y. J.; Camidge, D. R.; Shaw, A. T.; Solomon, B.; Maki, R. G.; Ou, S. H. I.; Dezube, B. J.; Janne, P. A.; Costa, D.
B.; Varella-Garcia, M.; Kim, W. H.; Lynch, T. J.; Fidias, P.; Stubbs, H.; Engelman, J. A.; Sequist, L. V.; Tan, W. W.; Gandhi, L.; Mino-
Kenudson, M.; Wei, G. C.; Shreeve, S. M.; Ratain, M. J.; Settleman, J.; Christensen, J. G.; Haber, D. A.; Wilner, K.; Salgia, R.; Shapiro, G. I.;
Clark, J. W.; Iafrate, A. J., Anaplastic Lymphoma Kinase Inhibition in Non-Small-Cell Lung Cancer. N. Engl. J. Med. 2010, 363 (18), 1693-
1703.
4
.
Lebeau, M. M.; Bitter, M. A.; Larson, R. A.; Doane, L. A.; Ellis, E. D.; Franklin, W. A.; Rubin, C. M.; Kadin, M. E.; Vardiman, J.
W., THE T(2-5)(P23-Q35) - A RECURRING CHROMOSOMAL ABNORMALITY IN KI-1-POSITIVE ANAPLASTIC LARGE CELL
LYMPHOMA. Leukemia 1989, 3 (12), 866-870.
5.
inflammatory myofibroblastic tumors. Cancer Res. 1999, 59 (12), 2776-2780.
Cook, J. R.; Dehner, L. P.; Collins, M. H.; Ma, Z. G.; Morris, S. W.; Coffin, C. M.; Hill, D. A., Anaplastic lymphoma kinase (ALK)
expression in the inflammatory myofibroblastic tumor - A comparative immunohistochemical study. Am. J. Surg. Pathol. 2001, 25 (11),
364-1371.
Griffin, C. A.; Hawkins, A. L.; Dvorak, C.; Henkle, C.; Ellingham, T.; Perlman, E. J., Recurrent involvement of 2p23 in
6.
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7.
Gascoyne, R. D.; Lamant, L.; Martin-Subero, J. I.; Lestou, V. S.; Harris, N. L.; Muller-Hermelink, H. K.; Seymour, J. F.;
Campbell, L. J.; Horsman, D. E.; Auvigne, I.; Espinos, E.; Siebert, R.; Delsol, G., ALK-positive diffuse large B-cell lymphoma is associated
with Clathrin-ALK rearrangements: report of 6 cases. Blood 2003, 102 (7), 2568-2573.
8
.
Jazii, F. R.; Najafi, Z.; Malekzadeh, R.; Conrads, T. P.; Ziaee, A. A.; Abnet, C.; Yazdznbod, M.; Karkhane, A. A.; Salekdeh, G. H.,
Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal
cancer. World J. Gastroenterol. 2006, 12 (44), 7104-7112.
9
.
Soda, M.; Choi, Y. L.; Enomoto, M.; Takada, S.; Yamashita, Y.; Ishikawa, S.; Fujiwara, S. I.; Watanabe, H.; Kurashina, K.;
Hatanaka, H.; Bando, M.; Ohno, S.; Ishikawa, Y.; Aburatani, H.; Niki, T.; Sohara, Y.; Sugiyama, Y.; Mano, H., Identification of the
transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007, 448 (7153), 561-U3.
10.
Janoueix-Lerosey, I.; Lequin, D.; Brugieres, L.; Ribeiro, A.; de Pontual, L.; Combaret, V.; Raynal, V.; Puisieux, A.;
Schleiermacher, G.; Pierron, G.; Valteau-Couanet, D.; Frebourg, T.; Michon, J.; Lyonnet, S.; Amiel, J.; Delattre, O., Somatic and germline
activating mutations of the ALK kinase receptor in neuroblastoma. Nature 2008, 455 (7215), 967-U51.
11.
George, R. E.; Sanda, T.; Hanna, M.; Frohling, S.; Luther, W.; Zhang, J. M.; Ahn, Y.; Zhou, W. J.; London, W. B.; McGrady, P.;
Xue, L. Q.; Zozulya, S.; Gregor, V. E.; Webb, T. R.; Gray, N. S.; Gilliland, D. G.; Diller, L.; Greulich, H.; Morris, S. W.; Meyerson, M.; Look,
A. T., Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature 2008, 455 (7215), 975-978.
12.
Friboulet, L.; Li, N. X.; Katayama, R.; Lee, C. C.; Gainor, J. F.; Crystal, A. S.; Michellys, P. Y.; Awad, M. M.; Yanagitani, N.; Kim,
S.; Pferdekamper, A. C.; Li, J.; Kasibhatla, S.; Sun, F.; Sun, X. Y.; Hua, S.; McNamara, P.; Mahmood, S.; Lockerman, E. L.; Fujita, N.;
Nishio, M.; Harris, J. L.; Shaw, A. T.; Engelman, J. A., The ALK Inhibitor ceritinib Overcomes crizotinib Resistance in Non-Small Cell
Lung Cancer. Cancer Discov. 2014, 4 (6), 662-673.
13.
(a) Solomon, B. J.; Mok, T.; Kim, D. W.; Wu, Y. L.; Nakagawa, K.; Mekhail, T.; Felip, E.; Cappuzzo, F.; Paolini, J.; Usari, T.; Iyer,
S.; Reisman, A.; Wilner, K. D.; Tursi, J.; Blackhall, F.; Investigators, P., First-Line crizotinib versus Chemotherapy in ALK-Positive Lung
Cancer. N. Engl. J. Med. 2014, 371 (23), 2167-2177; (b) Shaw, A. T.; Kim, D. W.; Nakagawa, K.; Seto, T.; Crino, L.; Ahn, M. J.; De Pas, T.;
Besse, B.; Solomon, B. J.; Blackhall, F.; Wu, Y. L.; Thomas, M.; O'Byrne, K. J.; Moro-Sibilot, D.; Camidge, D. R.; Mok, T.; Hirsh, V.; Riely,
G. J.; Iyer, S.; Tassell, V.; Polli, A.; Wilner, K. D.; Janne, P. A., crizotinib versus Chemotherapy in Advanced ALK-Positive Lung Cancer. N.
Engl. J. Med. 2013, 368 (25), 2385-2394.
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4.
oncologyꢀ: H&O. 2014, 12 (7), 429-439.
5. Costa, D. B.; Shaw, A. T.; Ou, S. H. I.; Solomon, B. J.; Riely, G. J.; Ahn, M. J.; Zhou, C. C.; Shreeve, M.; Selaru, P.; Polli, A.;
Awad MM, S. A., ALK Inhibitors in Non–Small Cell Lung Cancer: crizotinib and Beyond. Clinical advances in hematology &
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Schnell, P.; Wilner, K. D.; Wiltshire, R.; Camidge, D. R.; Crino, L., Clinical Experience With crizotinib in Patients With Advanced ALK-
Rearranged Non-Small-Cell Lung Cancer and Brain Metastases. J. Clin. Oncol. 2015, 33 (17), 1881-U41.
16.
Doebele, R. C.; Pilling, A. B.; Aisner, D. L.; Kutateladze, T. G.; Le, A. T.; Weickhardt, A. J.; Kondo, K. L.; Linderman, D. J.;
Heasley, L. E.; Franklin, W. A.; Varella-Garcia, M.; Camidge, D. R., Mechanisms of Resistance to crizotinib in Patients with ALK Gene
Rearranged Non-Small Cell Lung Cancer. Clin. Cancer Res. 2012, 18 (5), 1472-1482.
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