Bioorganic and Medicinal Chemistry Letters p. 2197 - 2200 (1996)
Update date:2022-08-11
Topics:
Riley, Andrew M.
Murphy, Christine T.
Lindley, Catherine J.
Westwick, John
Potter, Barry V. L.
The synthesis of racemic 6-deoxy-6-hydroxymethyl scyllo-inositol 1,2,4-trisphosphate is described. This compound is a highly potent agonist at the platelet D-myo-inositol 1,4,5-trisphosphate receptor, and it binds to the rat cerebellar receptor with an affinity equal to that of the natural ligand. These results suggest that the 5''-hydroxymethyl group of adenophostin A may contribute to its unusual potency.
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