6-Deoxy-6-hydroxymethyl scyllo-inositol 1,2,4-trisphosphate: A potent agonist at the inositol 1,4,5-trisphosphate receptor

DOI: 10.1016/0960-894X(96)00399-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2197 - 2200 (1996)

Update date:2022-08-11

Topics:

Authors:

Riley, Andrew M.

Murphy, Christine T.

Lindley, Catherine J.

Westwick, John

Potter, Barry V. L.

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Article abstract of DOI:10.1016/0960-894X(96)00399-X

The synthesis of racemic 6-deoxy-6-hydroxymethyl scyllo-inositol 1,2,4-trisphosphate is described. This compound is a highly potent agonist at the platelet D-myo-inositol 1,4,5-trisphosphate receptor, and it binds to the rat cerebellar receptor with an affinity equal to that of the natural ligand. These results suggest that the 5''-hydroxymethyl group of adenophostin A may contribute to its unusual potency.

Full text of DOI:10.1016/0960-894X(96)00399-X

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