Polymer-bound 4-benzylsulfonyl-1-triphenylphosphoranylidene-2-butanone as a tool for the solid-phase synthesis of substituted piperidin-4-one derivatives

Article abstract of DOI:10.1016/S0040-4039(98)01650-5

An efficient method for the construction of 2-substituted-piperidin-4- one derivatives on solid support has been developed using polymer-bound 4- benzylsulfonyl-1-triphenylphosphoranylidene-2-butanone as a convenient precursor for substituted divinyl ketones in the heterocyclization reaction with amines. The resin was released in a recyclable sulfinate form.