An improved large-scale preparation of benzimidazole-2-sulfonic acids and 2-chlorobenzimidazoles

Article abstract of DOI:10.1080/00397919808006874

An improved method for the preparation of benzimidazole-2-sulfonic acids from 2-mercaptobenzimidazoles has been developed which utilizes aqueous sodium percarbonate. 2-chlorobenzimidazoles were obtained in high yield from the corresponding sulfonic acids upon reaction with PCl₅ in POCl₃ on a gram-mole scale.

Full text of DOI:10.1080/00397919808006874

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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An Improved Large-
Scale Preparation of
Benzimidazole-2-Sulfonic Acids
and 2-Chlorobenzimidazoles.
Jack M. Hinkley a , Anthony R. Porcari a , John A.
Walker II b , Eric E. Swayze c & Leroy B. Townsend∗
a
a Department of Medicinal Chemistry, College
of Pharmacy; Department of Chemistry, College
of Literature, Science, and Arts, University of
Michigan, Ann Arbor, Michigan, 48109-1065
b SEQUUS Pharmaceuticals, 960 Hamilton Court,
Menlo Park, CA, 94087
c ISIS Pharmaceuticals, 2292 Faraday Avenue,
Carlsbad, CA, 92008
Version of record first published: 22 Aug 2006
To cite this article: Jack M. Hinkley, Anthony R. Porcari, John A. Walker II, Eric
E. Swayze & Leroy B. Townsend∗ (1998): An Improved Large-Scale Preparation
of Benzimidazole-2-Sulfonic Acids and 2-Chlorobenzimidazoles. , Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 28:9, 1703-1712
To link to this article: http://dx.doi.org/10.1080/00397919808006874

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