Phosphitylation of primary carboxamides. Synthesis of peptide- oligonucleotide conjugates with acylphosphoramidate linkages

Article abstract of DOI:10.1080/15257779508012481

N-acylphosphoramidates can be obtained from the reaction of phosphitylated primary carboxamides and an alcohol in the presence of an acid catalyst such as tetrazole and subsequent oxidation. The reaction is useful for the preparation of peptide-oligonucle

Full text of DOI:10.1080/15257779508012481

This article was downloaded by: [New York University]
On: 05 October 2014, At: 21:51
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered
office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK
Nucleosides and Nucleotides
Publication details, including instructions for authors and
subscription information:
http://www.tandfonline.com/loi/lncn19
Phosphitylation of Primary
Carboxamides. Synthesis of Peptide-
Oligonucleotide Conjugates with
Acylphosphoramidate Linkages
a
a
a
Anna Grandas , Jordi Robles & Enrique Pedroso
a
Departament de Química Orgànica, Facultat de Qúmica ,
Universitat de Barcelona , Martí i Franquès 1-11, E-08028,
Barcelona, Spain
Published online: 16 Feb 2007.
To cite this article: Anna Grandas , Jordi Robles & Enrique Pedroso (1995) Phosphitylation of Primary
Carboxamides. Synthesis of Peptide-Oligonucleotide Conjugates with Acylphosphoramidate Linkages,
Nucleosides and Nucleotides, 14:3-5, 825-828
To link to this article: http://dx.doi.org/10.1080/15257779508012481
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the information (the
“
Content”) contained in the publications on our platform. However, Taylor & Francis,
our agents, and our licensors make no representations or warranties whatsoever as to
the accuracy, completeness, or suitability for any purpose of the Content. Any opinions
and views expressed in this publication are the opinions and views of the authors,
and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content
should not be relied upon and should be independently verified with primary sources
of information. Taylor and Francis shall not be liable for any losses, actions, claims,
proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or
howsoever caused arising directly or indirectly in connection with, in relation to or arising
out of the use of the Content.
This article may be used for research, teaching, and private study purposes. Any
substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing,
systematic supply, or distribution in any form to anyone is expressly forbidden. Terms &
Conditions of access and use can be found at http://www.tandfonline.com/page/terms-
and-conditions