Anti-inflammatory, analgesic and antipyretic N-acetyl-Δ2-pyrazolines and dihydrothienocoumarines

Article abstract of DOI:10.1016/0223-5234(92)90142-N

1-Acetyl-3-(2-hydroxyphenyl)-5-(R,R′-aryl)-4,5-dihydro-(1H)pyrazoles (2a-o) were synthesized and showed anti-inflammatory and analgesic activity. The substituents on the 5-aryl group were necessary for biological activity. R-R′-aryl-2-dihydro-1,2(4H)thieno(2,3-c)benzo(e)pyranone-4 derivatives (3a-f) also showed analgesic and anti-inflammatory activity. The position and the number of the substituents caused a modulation of analgesic or anti-inflammatory activity of the N-acetyl-Δ²-pyrazoline2 and dihydrothienocoumarines 3. All compounds showed low antipyretic activity.