Journal of the American Chemical Society
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gle chiral polymer through the use of an appropriate achiral
external stimulus. To the best of our knowledge, this is the
first example of a CSP for HPLC capable of switching revers-
ibly its chiral recognition ability among three different states
using external achiral stimuli. It was also demonstrated how
the helical structure adopted can invert the retention time of
the two enantiomers of a chiral molecule, or can separate a
racemic mixture either in the P or M form but not in the oppo-
site. Further research to develop a more efficient switchable
CSP with higher chiral recognition ability toward many race-
mates is currently in progress in our laboratories.
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ASSOCIATED CONTENT
Supporting Information
The Supporting Information is available free of charge on the
ACS Publications website at DOI: XXXXXXXXXX.
Materials and methods and supporting data (PDF).
AUTHOR INFORMATION
Corresponding Author
*K. Maeda. E-mail: maeda@se.kanazawa-u.ac.jp.
*F. Freire. E-mail: felix.freire@usc.es
ACKNOWLEDGMENT
Authors thank Prof. Hasegawa (Kanazawa University) for his help
in the analysis of BArF salts. This work was supported by JSPS
KAKENHI Grant No. 16H04154 (Grants-in-Aid for Scientific
Research (B)), 18H05209 (Grant-in-Aid for Specially Promoted
Research), and 17H05361 (Coordination Asymmetry) (K.M.). We
of this manuscript.
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cal polymers: Synthesis, structures, and functions. Chem. Rev. 2009,
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