Tetrahedron Letters p. 4555 - 4558 (1995)
Update date:2022-08-11
Topics:
Myers, Andrew G.
Yoon, Taeyoung
Gleason, James L.
Both enantiomers of pseudoephedrine glycinamide <(+)- or (-)-1> were synthesized by either of two procedures: (1) a standard two-step coupling of N-Boc-Gly with pseudoephedrine followed by deprotection, or (2) a more economical one-step coupling reaction of Gly-OMe with pseudoephedrine mediated by LiCl and base.
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