Conversion dependence of enantioselective hydrogenation of (E)-α-phenylcinnamic acid on cinchonidine-modified Pd/TiO2 catalyst

Article abstract of DOI:10.1246/cl.1996.897

The enantioselectivity of a cinchonidine-modified Pd/TiO₂ catalyst varied with the extent of conversion in the hydrogenation of (E)-α-phenylcinnamic acid. The incremental enantioselectivity reached a maximum at an early stage of the reaction Under optimized reaction conditions, optical yields of up to 72%e.e. of (S)-(+)-2,3-diphenylpropionic acid were obtained at 100% conversion.