Phosphoramidate derivatives of d4T with improved anti-HIV efficacy retain fullactivity in thymidine kinase-deficient cells

Article abstract of DOI:10.1016/0960-894X(96)00195-3

New phosphate derivatives of the anti-HIV nucleoside analogue d4T were prepared as potential membrane-soluble pro-drugs of the bio-active free nucleotide. Some of the derivatives appear to have enhanced antiviral efficacy relative to the parent nucleoside