Tetrahedron p. 12781 - 12790 (1995)
Update date:2022-08-11
Topics:
Easton, Christopher J.
Pitt, Michael J.
Ward, Caroline M.
Treatment of pyrrolidin-2-ones with N-bromosuccinamide affords the corresponding 4,5-dibromo-γ-lactans. The introduced bromo substituents may be selectively displaced in ionic and radical reactions. The synthetic utility of this procedure is illustrated in regioselective elaborations of the dibromides, including the generation of a bicyclic tetrahydrofuropyrrolidinone system.
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