Synthesis of caged peptides using caged lysine: Application to the synthesis of caged AIP, a highly specific inhibitor of calmodulin-dependent protein kinase II

Article abstract of DOI:10.1016/S0960-894X(99)00140-7

N(α)-Fmoc-N(ε)-(2-nitrobenzyloxycarbonyl)-lysine has been prepared and used in the solid-phase synthesis of caged peptides. The synthesized caged AIP (cagedKcageKALRRQEAVDAL) showed characteristics required for caged peptides including a significantly red