Synthesis and resolution of 1,1-bi-8-methylisoquinoline: Formation of an optically active complex with high chiral recognition

Article abstract of DOI:10.1016/0957-4166(96)00107-3

The synthesis and resolution of 1,1-bi-8-methylisoquinoline (±)-5 is reported. An optically active palladium complex with high chiral recognition was formed during the complexation between a chiral palladium complex and the two enantiomers of (±)-5. The free energy barrier ΔGF(≠) for interconversion of enantiomers was estimated to be 97,2 KJ/mol at 40°C.