Solid-phase synthesis of unnatural α-amino acid derivatives using a resin-bound glycine cation equivalent

Article abstract of DOI:10.1016/S0040-4039(99)01101-6

Unnatural amino acids were synthesized on solid-phase by reaction of a resin-bound Schiff base with organoboranes. This novel use of a resin-bound glycine cation equivalent allows for the preparation of a variety of amino acid structural types not readily available by the complementary anionic equivalent.