Selective cleavage of the O6-diphenylcarbamoyl group from sugar-modified guanosines for incorporation into oligo-RNA

DOI: 10.1016/S0040-4039(99)01524-5

Source and publish data:

Tetrahedron Letters p. 7283 - 7284 (1999)

Update date:2022-08-22

Topics:

Authors:

Foeldesi, Andras

Trifonova, Anna

Dinya, Zoltan

Chattopadhyaya, Jyoti

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Article abstract of DOI:10.1016/S0040-4039(99)01524-5

A facile conversion of 2',3',5'-O-tri-(Bz, Tol or Ac)-N²-(Ac or iBu)-O⁶-DPC-guanosine to N²-(Ac or iBu)-guanosine has been achieved in 89-98% yield by short treatment with 90% aqueous TFA for smooth cleavage of the DPC gro

Full text of DOI:10.1016/S0040-4039(99)01524-5

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