Selective cleavage of the O6-diphenylcarbamoyl group from sugar-modified guanosines for incorporation into oligo-RNA

Article abstract of DOI:10.1016/S0040-4039(99)01524-5

A facile conversion of 2',3',5'-O-tri-(Bz, Tol or Ac)-N²-(Ac or iBu)-O⁶-DPC-guanosine to N²-(Ac or iBu)-guanosine has been achieved in 89-98% yield by short treatment with 90% aqueous TFA for smooth cleavage of the DPC gro