Microbial hydroxylation of 2-cycloalkylbenzoxazoles. Part I. Product spectrum obtained from Cunninghamella blakesleeana DSM 1906 and Bacillus megaterium DSM 32

Article abstract of DOI:10.1016/0957-4166(96)00030-4

2-Cycloalkyl-1,3-benzoxazoles and -thiazoles (ring sizes C-3 to C-8) were biotransformed using the title microorganisms. Products of preparative importance were (1S,3S)-3-(benz-1,3-oxazol-2-yl)cyclopentan-1-ol 6, (1R)-3-(benz-1,3-oxazol-2-yl)cyclopentan-1-one 8, (1R,2R)-2-(benz-1,3-oxazol-2-yl)cyclohexan-1-ol 14 and the corresponding cycloheptanol and cycloheptanone derivatives.