Steroidal saponins from Nolina recurvata stems and their inhibitory activity on cyclic AMP phosphodiesterase

Article abstract of DOI:10.1016/0031-9422(96)00107-0

Seven steroidal saponins were isolated from the stems of Nolina recurvata, five of which appeared to be new compounds and were assigned as spirosta-5,25(27)-diene-1β,3β-diol (neuruscogenin) 1-O-{O-α-L- rhamnopyranosyl-(1 → 2)-O-[β-D-xylopyranosyl-(1 → 3)-α-L- arabinopyranoside}, (25S)-spirost-5-ene-1β,3β-diol [(25S)-ruscogenin] 1- O-{O-α-L-rhamnopyranosyl-(1 → 2)-O-[β-D-xylopyranosyl-(1 → 3)]-α-L- arabinopyranoside}, neuruscogenin 1-O-{O-α-L-rhamnopyranosyl-(1 → 2)-O- [β-D-xylopyranosyl-(1 → 3)]-β-D-fucopyranoside}, 26-O-β-D- glucopyranosyl-22-O-methylfurosta-5,25(27)-diene-1β,3β,22ζ,26-tetrol 1-O- {-O-α-L-rhamnopyranosyl-(1 → 2)-O-[β-D-xylopyranosyl-(1 → 3)]-α-L- arabinopyranoside} and 26-O-β-D-glucopyranosylfurosta-5,20(22),25(27)- triene-1β,3β,26-triol 1-O-{O-α-L-rhamnopyranosyl-(1 → 2)-α-L- arabinopyranoside}. The isolated saponins were evaluated for their inhibitory activity on cyclic AMP phosphodiesterase to identify new compounds with medicinal potential.