Stereoselective synthesis of (S)-(+)-αM4CPG, a selective antagonist of metabotropic glutamate receptors

Article abstract of DOI:10.1016/0957-4166(96)00182-6

The synthesis, from (R)-4-hydroxyphenylglycine, of (+)-α-methyl-4- carboxy-phenylglycine ((+)-αM4CPG), a new and selective antagonist of metabotropic glutamate receptor, and assignment of its absolute configuration, are described.