Aragusterol A: A Potent Antitumor Marine Steroid from the Okinawan Spronge of the Genus, Xestospongia

Article abstract of DOI:10.1016/S0040-4039(00)73731-2

Aragusterol A, a new marine steroid possesing antitumor activity , was isolated from Okinawan sponge of the genus Xestospongia and its structure was determined by spectroscopic analysis and chemical evidence.The compoumd strongly inhibited the cell proliferation of KB, HeLaS3, P388 and LoVo cells in vitro, and also showed potent in vivo antitumor activity toward P388 in mice and L1210 in mice.