The synthesis of the novel adenosine agonists, exo- and endo-N6-(5,6-epoxynorborn-2-yl)adenosine

Article abstract of DOI:10.1016/0040-4020(96)00144-5

Both racemic exo and endo isomers of N⁶-(5,6-epoxynorborn-2-yl)adenosine have been synthesised and shown to be potent agonists for the A₁ adenosine receptor. Crucial to the preparation of these compounds is the synthesis of exo and endo norbornenylamines which are accessed through an optimised Curtius rearrangement.