Erratum: A review of U.S. patents in the field of organic process development published during august and september 2009 (Organic Process Research and Development (2010) 14 (8-18))

Full text of DOI:10.1021/op1000429

Organic Process Research & Development 2010, 14, 481–481
Additions & Corrections
A Review of U.S. Patents in the Field of Organic Process
Development Published During August and September 2009
Keith Turner*
[Org. Process Res. DeV. 2010, 14, 8–18].
On page 10 in the review of U.S. Patent 7,569,732 there
were inaccuracies in Reaction 4 and associated text. The
molecules 12, 13, 15, and 16 in Reaction 4 were inadvertently
drawn as aldehydes instead of methyl ketones. The correct
reaction scheme is shown below, and sentences two, three, four,
and the advantages should read as follows:
The other structural isomers of 13 are less potent, and so
any preparation of this compound is aimed at increasing the
amount of the desired isomer. Cyclisation of 12 using H3PO4
is known to produce 13 plus 15, and since the latter cannot be
converted to 13, its formation is undesirable. Reaction 4 shows
the improved route that produces 13 plus 14 and 16, and these
can both be converted to 13. The amount of 15 formed may be
present at between 1 and 5% by weight although it is reported
that it is usually completely absent from the reaction mixture.
Advantages
The advantage of the process is that it gives an improved
yield and higher-purity product compared to the method that
uses H3PO4.
Reaction 4
OP1000429
10.1021/op1000429  2010 American Chemical Society
Published on Web 02/19/2010
Vol. 14, No. 2, 2010 / Organic Process Research & Development
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