Studies on the constituents of Cimicifuga species. XX. Absolute stereostructures of cimicifugoside and actein from Cimicifu simplex WORMSK

Article abstract of DOI:10.1248/cpb.46.467

The absolute stereostructues of cimicifugoside (1) and actein (2) from Cimicifuga simplex were established by X-ray crystal analysis of 26(S)-O- methylcimicifugenin A (1cS) prepared from 1, negative CD curves of 26-O- methyl-3-keto-cimicifugenins (1dS, 1dR), comparative analysis of ¹H- and ¹³C-NMR spectra of 1, 2 and their derivatives, and preparation of 2 from 1 by hydrogenation: 20(R), 23(R), 24(R), 25(S), 26 (R,S)-16β:23; 23:26; 24:25- triepoxy-12β-acetoxy-3β,26-dihydroxy-9,19-cyclolanost-7-ene 3-O-β-D- xylopyranoside for 1 and 20(R), 23(R), 24(R), 25(S), 26(R,S)-16β: 23; 23: 26; 24:25-triepoxy-12β-acetoxy-3β,26-dihydroxy-9,19-cyclolanostane 3-O-β- D-xylopyranoside for 2.

Full text of DOI:10.1248/cpb.46.467

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