Reaction of the 2-(bromodifluoromethyl)benzoxazole with tetrakis(dimethylamino)ethylene (TDAE) in the presence of aldehydes. A convenient synthesis of 2-(difluoromethyl)benzoxazole alcohols.

DOI: 10.1016/S0040-4039(96)02440-9

Source and publish data:

Tetrahedron Letters p. 821 - 824 (1997)

Update date:2022-08-11

Topics:

Authors:

Burkholder, Conrad

Dolbier Jr., William R.

Medebielle, Maurice

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Article abstract of DOI:10.1016/S0040-4039(96)02440-9

Tetrakis(dimethylamino)ethylene (TDAE) was found to be an effective reductant of the 2-(bromodifluoromethyl)benzoxazole 1. The generated 2-(difluoromethyl) benzoxazole anion was trapped with several aldehydes 2-9, under mild conditions, to give the corres

Full text of DOI:10.1016/S0040-4039(96)02440-9

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