Archiv der Pharmazie p. 541 - 549 (1996)
Update date:2022-08-11
Topics:
Moldvai
Gacs-Baitz
Balazs
Incze
Szantay
Hydroxyindolones (1-6, 15-16) were transformed into isatinylidenes (7,9-13, 17-19) by dehydration with 4-toluenesulfonic acid. The dimer-type compounds (14, 20) were also isolated in a few cases. The obtained isatinylidenes were transformed into 3-spiro-cyclopropane-oxindoles (21-32) with dimethyloxosulfonium methylide. Compound 22 shows protective effects against hypobaric hypoxia and triethyltin induced brain edema.
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Doi:10.1016/S0040-4039(01)89067-5
(1965)Doi:10.1134/S1070428016110221
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(2020)Doi:10.1021/acs.jmedchem.6b00308
(2016)Doi:10.1021/jacs.9b13359
(2020)Doi:10.1021/jo01121a019
(1955)