An improved large scale synthesis of 2-amino-4-chloropyridine and its use for the convenient preparation of various polychlorinated 2-aminopyridines

Article abstract of DOI:10.1080/00397919708004207

An efficient large scale synthesis of 2-amino-4-chloropyridine (3) has been achieved through a modification of existing literature procedures. Compound 3 was used to prepare the previously unreported 2-amino-4,5-dichloropyridine (4). The known 2-amino-3,4-dichloropyridine (5) and 2-amino-3,4,5-trichloropyridine (6) were pepared from 3 by new routes and in higher yields than previously reported.

Full text of DOI:10.1080/00397919708004207

This article was downloaded by: [Universitaets und Landesbibliothek]
On: 23 December 2013, At: 09:32
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number:
1072954 Registered office: Mortimer House, 37-41 Mortimer Street,
London W1T 3JH, UK
Synthetic Communications:
An International Journal
for Rapid Communication of
Synthetic Organic Chemistry
Publication details, including instructions for
authors and subscription information:
http://www.tandfonline.com/loi/lsyc20
An Improved Large Scale
Synthesis of 2-Amino-4-
chloropyridine and Its
Use for the Convenient
Preparation of Various
Polychlorinated 2-
Aminopyridines
Kristjan S. Gudmundsson a , Jack M. Hinkley a ,
Michael S. Brieger a , John C. Drach a & Leroy B.
Townsend a
a Department of Medicinal Chemistry, College
of Pharmacy and Department of Chemistry,
College of Literature, Science and the Arts ,
The University of Michigan , Ann Arbor, MI,
48109-1065
Published online: 22 Aug 2006.
To cite this article: Kristjan S. Gudmundsson , Jack M. Hinkley , Michael S.
Brieger , John C. Drach & Leroy B. Townsend (1997) An Improved Large Scale
Synthesis of 2-Amino-4-chloropyridine and Its Use for the Convenient Preparation
of Various Polychlorinated 2-Aminopyridines, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry,
27:5, 861-870, DOI: 10.1080/00397919708004207
To link to this article: http://dx.doi.org/10.1080/00397919708004207

PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all
the information (the “Content”) contained in the publications on our
platform. However, Taylor & Francis, our agents, and our licensors
make no representations or warranties whatsoever as to the accuracy,
completeness, or suitability for any purpose of the Content. Any opinions
and views expressed in this publication are the opinions and views of
the authors, and are not the views of or endorsed by Taylor & Francis.
The accuracy of the Content should not be relied upon and should be
independently verified with primary sources of information. Taylor and
Francis shall not be liable for any losses, actions, claims, proceedings,
demands, costs, expenses, damages, and other liabilities whatsoever
or howsoever caused arising directly or indirectly in connection with, in
relation to or arising out of the use of the Content.
This article may be used for research, teaching, and private study
purposes. Any substantial or systematic reproduction, redistribution,
reselling, loan, sub-licensing, systematic supply, or distribution in any
form to anyone is expressly forbidden. Terms & Conditions of access
and use can be found at http://www.tandfonline.com/page/terms-and-
conditions