N-chloro-N-sodio-2-trimethylsilyl ethyl carbamate: A new nitrogen source for the catalytic asymmetric aminohydroxylation

Article abstract of DOI:10.1016/S0040-4039(98)00644-3

The use of N-chloro-N-sodio-2-trimethylsilyl ethyl carbamate in the osmium-catalyzed asymmetric aminohydroxylation of alkenes leads to enantiomerically enriched N-trimethylsilylethoxycarbonyl (TeoC) protected aminoalcohols in yields up tO 80% and ee's up to 99%.