Synthesis ofnucleoside 3'-thiophosphates in one step procedure

Article abstract of DOI:10.1080/15257779908041610

A mild and efficient one-step method of thiophosphorylation was devised for acid-sensitive nucleosides. The procedure is based on thiophosphorylation of nucleoside magnesium alkoxide by 2-chloro-2-thio-l,3,2-dioxaphospholane. The utility and efficiency of this method combined with deprotection of the resulting cyclic triester were demonstrated by its application to the synthesis of both adenosine 3'- and 5'thiophosphates. The procedure does not require protection of the exocyclic amino group and can be successfully used for the thiophosphorylation of nucleosides that are unusually sensitive to depurination. Copyright 1999 by Marcel Dekker, Inc.

Full text of DOI:10.1080/15257779908041610

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Nucleosides and Nucleotides
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Synthesis of Nucleoside 3′-
Thiophosphates in One Step Procedure
a
a
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Maciej B. Szczepanik , Laurent Désaubry & Roger A. Johnson
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Department of Physiology and Biophysics, Health Sciences Center ,
State University of New York at Stony Brook , Stony Brook, NY,
11794, USA
Published online: 04 Oct 2006.
To cite this article: Maciej B. Szczepanik , Laurent Désaubry & Roger A. Johnson (1999) Synthesis of
Nucleoside 3′-Thiophosphates in One Step Procedure, Nucleosides and Nucleotides, 18:4-5, 951-953,
DOI: 10.1080/15257779908041610
To link to this article: http://dx.doi.org/10.1080/15257779908041610
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