Bioorganic and Medicinal Chemistry Letters p. 1572 - 1575 (2019)
Update date:2022-08-29
Topics:
Olawode, Emmanuel O.
Tandlich, Roman
Prinsloo, Earl
Isaacs, Michelle
Hoppe, Heinrich
Seldon, Ronnett
Warner, Digby F.
Steenkamp, Vanessa
Kaye, Perry T.
A series of novel, substituted 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones have been prepared and shown to exhibit promising concentration-dependent activity against human SH-SY5Y cells, Plasmodium falciparum, Mycobacterium tuberculosis and P. aeruginosa. Substituent effects on observed bioactivity have been explored; the para-fluorophenyl derivative 3d exhibited activity across the range of the bioassays employed, indicating the potential of the 2-chloro-3-[(4-arylthiazol-2-yl)amino]-1,4-naphthoquinone scaffold in the development of novel, broad spectrum therapeutics.
View MoreShanghai AoBo Bio-Pharmaceutical Technology Co., Ltd.
Contact:+86-21-51320130-801, 816
Address:Room 601, No. 1011, Halei Road, Zhangjiang High-Tech Park, Pudong, Shanghai
Shandong Hongxiang Zinc Co., Ltd
Contact:086-0311-66187879
Address:DaWang developing zone
shijiazhuang alkay chemicals co..ltd(expird)
Contact:86-311-67692035
Address:2601,juntang building,qiaodong district,shijiazhuang
Sichuan Sangao Biochemical Co., Ltd
Contact:+86-28-84874233
Address:19F, Bldg.2, Shudu Center, Tianfu 2nd St., Hi-tech zone, Chengdu 610041, Sichuan Province, China.
Wuhan Soleado Technology Co.,Ltd.
Contact:86-2783341481 18971291927
Address:RM2405 Unit 1 Builing 1, Taiyin Tower, Changqing Road,Wuhan China
Doi:10.1039/b718544h
(2008)Doi:10.1007/s11164-012-0962-6
(2014)Doi:10.1021/jm020871e
(2002)Doi:10.1016/0040-4020(96)00903-9
(1996)Doi:10.1002/hlca.19720550712
(1972)Doi:10.1021/ic010661c
(2002)