Chemistry of Natural Compounds p. 603 - 607 (1989)
Update date:2022-08-16
Topics:
Dalimov, D. N.
Mukhamedzhanova, E. N.
Shneivais, V. B.
Biktimirov, L.
Ismailov, A. I.
Kamaev, F. G.
The synthesis has been effected of new gossypol derivatives using piperidino- and morpholinoethylamines.According to their PMR spectra, these substances exist in the keto-amine form.Their action on the peroxidation of lipids (POL) of various biosubstrates has been studied.Gossypol bis(piperidinoethylimine) and bis(morpholinoethylimine) in concentrations of 1*1E-7 - 5*1E-6 mM exert a pronounced antioxidant action on human blood serum and rat brain synaptosomes.In the same concentrations, these substances suppressed the POL in enzymatic and nonenzymatic systems of the oxidation of rat liver microsomes.
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