CONJUGATE ADDITIONS WITH CHIRAL LITHIUM (2-PYRIDYL)-CUPRATE

Article abstract of DOI:10.1016/S0022-328X(00)98544-9

The cuprate (LiPyR^*Cu) transfers its pyridyl group to 4-phenyl-3-buten-2-one at -60 deg C in ether to give (+)-4-phenyl-4-(2-pyridyl)-2-butanone in good yield with some enantioselectivity (23percent e.e.).Additions to ethyl 3-phenyl-propenoate and to 5-phenyl-2,2-dimethyl-4-penten-3-one give good yields but low inductions.Induction is also low on transfer of a phenyl group from LiPhR^*Cu to 4-(2-pyridyl)-buten-2-one.