Chemical and Pharmaceutical Bulletin p. 357 - 361 (1993)
Update date:2022-08-11
Topics:
Kawai
Kitano
Mutoh
Hata
The reaction of dihydroxo(1R,2R-cyclohexanediamine)platinum(II) with 2,4-dioxopentanoic acid gave a water-soluble complex, (1R,2R-cyclohexanediamine-N,N')[2-hydroxy-4-oxo-2-pentenoato(2-)-O2]p latinum(II). The structure of the complex was determined by X-ray crystal analysis. The data indicated a chelation of the acetylacetonato part of 2,4-dioxo-pentanoic acid to platinum(II). The complex showed moderate antitumor activity against murine leukemia L1210 in mice (T/C = 195% at a dose of 200 mg/kg) and high activity against cisplatin-resistant L1210 leukemia (T/C = 275% at a dose of 25 mg/kg).
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Doi:10.1016/0301-0104(83)85333-6
(1983)Doi:10.1039/d0sc04329j
(2020)Doi:10.1016/j.bmc.2015.07.010
(2015)Doi:10.1246/cl.140811
(2014)Doi:10.1007/s11172-009-0009-3
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(1994)
