Synthetic Studies toward Verrucarol. 1. Synthesis of the AB Ring System

Article abstract of DOI:10.1021/jo01312a003

A synthetic route to the AB ring system of verrucarol is described.After two routes employing intramolecular cyclization failed, the Diels-Alder reaction of methyl coumalate and isoprene afforded bicyclic lactone 13.Transformation of 13 into hydroxy lacto