Synthesis of 3,4,3 LI 1,2 HOPO labelled with 14C

Article abstract of DOI:10.1002/jlcr.427

3,4,3 LI 1,2 HOPO 1 or LIHOPO (1,5,10,14-tetra (1-hydroxy-2-pyridone-6-oyl)-1,5,10,14-tetraazatetradecane.) is a decorporation agent used against actinides. It was synthesised labelled with carbon 14 with a view to metabolism studies. [6,9-¹⁴C]-LIHOPO 2 was obtained in two radioactive steps through a very convenient synthesis in 50% radioactive yield from commercially available [1,4-¹⁴C]-spermine, hydrochloride and 1-benzyloxy-6-oxo-1,6-dihydropyridine-2-carbonyl chloride 7. The synthesis of 7 is also described.