Carbaxylosides of 4-ethyl-2-oxo-2H-benzopyran-7-yl as nonhydrolyzable, orally active venous antithrombotic agents

Article abstract of DOI:10.1016/S0960-894X(98)00283-2

A (-)-conduritol F derivative was condensed with 4-ethyl-7-hydroxy-2H- 1-benzopyran-2-one and converted into (+)-4-ethyl-7-[(1'R,2'S,3'S,4'R)- 2',3',4'-trihydroxycyclohexyloxy]-2H-1-benzopyran-2-one ((+)-2). Enantiomer (-)-2 was obtained from a (+)-conduritol F derivative. The carbaxyloside (- )-2 with the L-xylose configuration was more active than (+)-2 in the Wessler's model.