Diaryl-substituted (Dihydro)pyrrolo[3,2,1- hi ]indoles, a class of potent COX-2 inhibitors with tricyclic core structure

Article abstract of DOI:10.1021/acs.joc.5b00537

A new compound class of diaryl-substituted heterocycles with tricyclic dihydropyrrolo[3,2,1-hi]indole and pyrrolo[3,2,1-hi]indole core structures has been designed and was synthesized by a modular sequence of Friedel-Crafts acylation, amide formation, and