New Derivatizing Agents for Amino Acids and Peptides. 1. Facile Synthesis of N-Substituted 1-Cyanobenzisoindoles and Their Spectroscopic Properties

Article abstract of DOI:10.1021/jo00371a013

2,3-Naphthalenedicarboxaldehyde (NDA) is shown to be a very useful reagent for the derivatization of primary amines, amino acids, and small peptides.The reaction of these amino compounds with NDA and cyanide ion produces highly fluorescent 2-substituted 1-cyanobenzisoindoles that are relatively stable.The physical and fluorescent properties of a variety of 1,2-disubstituted benzisoindoles are presented.