An efficient chemo-enzymatic synthesis of α-amino-β-hydroxy-γ butyrolactone

Article abstract of DOI:10.1016/0040-4039(95)00924-2

The synthesis of (25,3R)-2-amino-3-hydroxybutyrolactone, a precursor of the monobactam antibiotic Carunoman, has been accomplished in three steps involving the use of L-threonine aldolase.