Synthesis and enzymatic cyclization of (3S)-14-fluoro-2,3-oxidosqualene

DOI: 10.1016/S0040-4039(98)02197-2

Source and publish data:

Tetrahedron Letters p. 9385 - 9388 (1998)

Update date:2022-08-16

Topics:

Authors:

Robustell, Brian J.

Abe, Ikuro

Prestwicht, Glenn D.

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Article abstract of DOI:10.1016/S0040-4039(98)02197-2

A convergent asymmetric synthesis led to (3S)-14-fluoro-2,3- oxidosqualene (14-FOS, 16), which was cyclized by bacterial squalene:hopane cyclase to a monocarbocyclic product with a bridged ether and a 2:3 mixture of bicyclic alcohols. 14-FOS was neither a

Full text of DOI:10.1016/S0040-4039(98)02197-2

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