Dehydroabietic acid derivatives as a novel scaffold for large-conductance calcium-activated K+ channel openers

Article abstract of DOI:10.1016/j.bmcl.2003.08.072

We found that the dehydroabietic acid structure is a new scaffold for chemical modulators of large-conductance calcium-activated K⁺ channels (BK channels). Structure-activity relationship (SAR) studies of the dehydroabietic acid derivatives and related non-aromatic compounds such as pimaric acid revealed the importance of the carboxyl functionality and an appropriate hydrophobic moiety of the molecules for BK channel-opening ability.