Novel synthesis of 3-carboxamidolactam derivatives via palladium-catalysed aminocarbonylation

Article abstract of DOI:10.1016/j.tet.2018.08.046

Aminocarbonylation of alkenyl and (hetero)aryl iodides using medium-sized 3-aminolactams as N-nucleophiles was carried out in the presence of in situ palladium(0) catalysts. While the iodoalkenes were converted to the corresponding carboxamide under mild