Design, synthesis, and opioid receptor binding of some novel benzazepine constrained leucine enkephalin mimetics

Article abstract of DOI:10.1006/bioo.1994.1024

An N-substituted 2-benzazepine, previously reported to possess morphine-like analgesic activity in vivo, was adapted for use as a constrained mimic of the N-terminal residues of leucine enkephalin. Molecular modeling was used to evaluate the suitability o