Synthesis and Study of a Methoxyhydroperoxide-Androstenedione Derivative; Analogue of a Potential Aromatase Intermediate

DOI: 10.1039/c39860001651

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1651 - 1653 (1986)

Update date:2022-08-25

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Authors:

Cole, Philip A.

Robinson, Cecil H.

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Article abstract of DOI:10.1039/c39860001651

A methoxyhydroperoxide analogue (12) to a proposed aromatase intermediate has been synthesized by ozonolysis of metoxyvinyl compound (7) in the presence of methanol; it has been shown not to produce estrone with or without acetylation, but the free hydroperoxide apparently undergoes a facile, stereospecific intramolecular epoxidation.

Full text of DOI:10.1039/c39860001651

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