Stereoselective synthesis of α-substituted ulosonic acids by magnesio-Reformatsky reactions

Article abstract of DOI:10.1016/S0040-4020(97)00813-2

A new method of homologation of aldonolactones allowing the incorporation of propionate units with excellent chemo- and stereoselectivity is performed by the magnesium-graphite mediated reaction between Oppolzer sultam derived α-halogenated amides and an aldonolactone.