Aromatic β-sheet foldamers based on tertiary squaramides

Article abstract of DOI:10.1039/c9cc04849a

The preference of N,N-aryl, alkyl tertiary amides for cis conformations has been exploited through the use of tertiary squaramides as hairpin turn units that promote the folding of aromatic β-sheets. Head-to-head aromatic arrangements were shown to prevail in sufficiently long bent aromatic sequences.

Full text of DOI:10.1039/c9cc04849a

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Nagai, P. Mayer, V. Maurizot, A. Tanatani and I. Huc, Chem. Commun., 2019, DOI: 10.1039/C9CC04849A.
Volume 54
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January 2018
Pages 1-112
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ISSN 1359-7345
COMMUNICATION
S. J. Connon, M. O. Senge et al.
Conformational control of nonplanar free base porphyrins:
towards bifunctional catalysts of tunable basicity
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Page 5 of 5
ChemComm
View Article Online
DOI: 10.1039/C9CC04849A
Suitably substituted aryl-methyl tertiary squaramides are convenient and efficient at promoting
hairpin turns in aromatic amide sequences.