Preparation of nitriles by the modification of Mitsunobu-Wilk procedure III carbon elongation of hydroxy esters

Article abstract of DOI:10.1080/00397919608003695

An efficient one-step procedure for the conversion of hydroxy esters into the corresponding nitrile esters using triphenylphosphine (PPh₃)-diethyl azodicarboxylate (DEAD) in the presence of acetone cyanohydrin is described.

Full text of DOI:10.1080/00397919608003695

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Preparation of Nitriles
by the Modification of
Mitsunobu-Wilk Procedure
III Carbon Elongation of
Hydroxy Esters
Mohammed C. Aesa a , Gábor Baán a , Lajos
Novák b & Csaba Szántay a b
a Central Research Institute for Chemistry,
Hungarian Academy of Sciences , P.O. Box 17,
H-1525
b Institute for Organic Chemistry, Technical
University , 1111, Budapest, Gellért, tér 4,
Hungary
Published online: 21 Aug 2006.
To cite this article: Mohammed C. Aesa , Gábor Baán , Lajos Novák & Csaba
Szántay (1996) Preparation of Nitriles by the Modification of Mitsunobu-Wilk
Procedure III Carbon Elongation of Hydroxy Esters, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry,
26:5, 909-914, DOI: 10.1080/00397919608003695
To link to this article: http://dx.doi.org/10.1080/00397919608003695
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